Endocrine Abstracts

Introduction: The discovery of incidental thyroid carcinomas (ITC) in patients undergoing surgery for a benign disease range between 3 and 16% of cases. During years, patients with hyperthyroidism were considered protected by TSH suppression (TSH is well known factor that favors the development of thyroid cancer). Thyroid size might be a predictive factor due to the excess of thyroid tissue prone to mutations. The knowledge of determining factors foretelling the presence of un...

Thyroid carcinoma is a rare extraintestinal manifestation of colonic familial adenomatous polyposis (FAP). This syndrome is caused by germline mutations in adenomatous polyposis coli (APC) gene, on chromosome 5q21-q22. Many patients manifest various extracolonic features: upper gastrointestinal adenomas, congenital hypertrophic retinal pigment epithelial lesions, desmoids tumors, and thyroid, adrenal and brain cancers. It has been reported an incidence of 1.2% of thyroid carci...

Bilateral cervical exploration has been the gold standard in parathyroid surgery. Nowadays, the preoperative localization procedures have facilitated the minimally invasive surgery. This study aims to analyze the influence of thyroid disease in Tc99m-sestamibi scintigraphy (MIBI) results.A series of 154 patients with PHP who underwent parathyroidectomy was reviewed. Patients were divided into two groups: group 1 (G1, 58 patients) with thyroid diseases, a...

Autoimmune polyendocrinopathy syndromes (APS) gather a wide range of diseases. The association of autoimmune thyroid disease (ATD) with other organ specific diseases is frequent. Atrophic body gastritis (ABP) is characterized by the loss of ClH and intrinsic factor (IF) production. Both ATD and ABP are known to be associated since 1960 but there are scarce publications describing its clinical features.We review patients with this association selected fro...

The simultaneous occurrence of MTC and PTC in the same thyroid can be observed as a mixed tumour folliculo-medullar (OMS 1988) or as a collision tumour separated by normal thyroid parenchyma, which has only been described in less than thirty patients. We report two cases.Case 1: A 72 years old woman who underwent total thyroidectomy for a multinodular goiter. Histology showed a 2.5 cm CPT in the left lobe and a 4.5 cm CMT in the right lobe. She received ...

Introduction: CCHD comprises a number of different congenital heart defects associated with elevated pulmonary artery pressure and pulmonary vascular resistance, resulting in a reversed or bidirectional shunt (Eisenmenger syndrome). These entities develop systemic hypoxia. Pheochromocytoma and paraganglioma (PHEO/PG) are neuroendocrine tumours. Several inheritance genetic alterations have been reported in PHEO/PG syndromes. A pathogenic association between these entities is pr...

Introduction: When facing with non-functioning pituitary macroadenomas (NFPMA), radiological invasion is determinant to surgical approach, apart from histological biomarkers of pituitary tumor aggressiveness (Ki-67; p53 and mitotic index). Invasive tumors usually need additional surgery and/or radiotherapy. There are no much studies describing epidemiological data on aggressive pituitary tumors in clinical practice. We provide information regarding the radiological findings of...

Introduction: Hypoparathyroidism (hypoPT) is the most frequent complication after thyroid surgery, usually as transient hypocalcaemia. Permanent parathyroid lesion is less frequent, but it can extend hospital stay and complicate postoperative management. Several preoperative factors predicting the development of hypoPT have been identified, including advanced age, hyperthyroidism, surgical experience and others. We evaluate the role of some potentially predictive factors in ou...

Fine-needle aspiration cytology (FNAC) remains the mainstay in the study of thyroid nodules, with cytologic adequate specimens in almost 85% of cases in expert hands. Apart from the limitation of inadequate samples, there are false negative diagnoses in some cases, particularly in larger (>3 cm) nodules. Considering this, Large-needle biopsy (LNB) could be useful to improve diagnostic precision. We review the pathology reports (PR) of more than 100 patients operated since ...

Introduction: BRAF (V600E) mutation is the most frequent detected genetic change in papillary thyroid cancer (PTC). Its presence has been related to aggressive clinical and pathological features. Therefore, BRAF mutation has drawn considerable interest as a potential prognostic factor for PTC. The presence of the mutation confers the tumour a disability to uptake RAI, diminishing the therapeutic tools. However if this feature is related to some kind of tumour dedifferentiation...